Question 1

Which of the following immunoglobulins is able to activate complement?

Accepted Answer

A)   IgA
B)   IgD
C)   IgE
D)   IgME) A) and B)
F) A) and C)

Question 2

What reagent is present in a CH50 assay and absent in an AH50 assay?

Accepted Answer

A)   Calcium
B)   Red blood cells
C)   Ethylene glycol
D)   MagnesiumE) A) and C)
F) B) and C)

Question 3

Kidney glomeruli can become obstructed with immune complexes as a result of:

Accepted Answer

A)   properdin deficiency.
B)   inadequate C3b-mediated opsonization.
C)   membrane attack complex formation.
D)   autoantibodies that bind C3bBb.E) A) and C)
F) None of the above

Question 4

Lack of the complement inhibitor C1INH results in which disease?

Accepted Answer

A)   Hereditary angioedema
B)   Paroxysmal nocturnal hemoglobinuria
C)   Immune complex disease
D)   MeningitisE) A) and B)
F) None of the above

Question 5

Which of the following is the correct order of activation of complement in the lectin activation pathway?

Accepted Answer

A)   C1, C4, C2, C3
B)   MBL, C4, C2, C3
C)   C3, factor B, C3
D)   MBL, C2, C3, C4E) None of the above
F) C) and D)

Question 6

Which of the following acts as an opsonin?

Accepted Answer

A)   IgD
B)   C3b
C)   C5a
D)   IL-2E) A) and D)
F) B) and C)

Question 7

Binding of a lectin to a sugar found in bacteria and fungi occurs in which complement pathway?

Accepted Answer

A)   Alternative pathway
B)   Classical pathway
C)   MBL pathway 
D)   All of the aboveE) B) and D)
F) A) and D)

Question 8

Which factors are found in all three pathways?

Accepted Answer

A)   Factors B and D
B)   C4, C2, and C3
C)   C5 through C9
D)   C1qrs, C3, and C5E) A) and B)
F) All of the above

Question 9

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Accepted Answer

A)   C1q, C1r, and C1s.
B)   C4 and C2.
C)   C5 and C3.
D)   C5, C6, C7, and C8E) A) and B)
F) A) and C)

Question 10

Which statement about complement components is most accurate?

Accepted Answer

A)   They all are active enzymes.
B)   They are synthesized only when antigen is present.
C)   They play a major part in the inflammatory response.
D)   They are mainly produced in lymphoid tissue.E) A) and C)
F) A) and D)

Question 11

In the alternate pathway,factor B must bind to which of the following to initiate the cascade?

Accepted Answer

A)   Factor I
B)   C3b
C)   C4b
D)   ProperdinE) A) and B)
F) None of the above

Question 12

Formation of the membrane attack complex (C5b-C9) is stopped by which factor?

Accepted Answer

A)   Factor H
B)   Factor I
C)   C1INH
D)   S proteinE) A) and D)
F) C) and D)

Question 13

Which of the following represents C3 convertase?

Accepted Answer

A)   C4b2a3b
B)   C3bBbP
C)   C1qrs
D)   BbHE) None of the above
F) A) and B)

Question 14

Lack of the complement components C5 through C9 may result in which condition?

Accepted Answer

A)   Neisseria infection
B)   Paroxysmal nocturnal hemoglobinuria
C)   Atherosclerosis
D)   MeningitisE) All of the above
F) A) and D)

Question 15

Which of the following is a characteristic of complement?

Accepted Answer

A)   It is activated by IgE in the classical pathway.
B)   It cannot be activated by molecules other than antigen-antibody complexes.
C)   It plays a role in the lysis of target cells coated with specific antibodies.
D)   It is enhanced by decay-accelerating factor.E) A) and B)
F) None of the above

Question 16

The lectin pathway is initiated by the presence of which of the following?

Accepted Answer

A)   Antibody
B)   C3
C)   Mannose
D)   C1qrsE) A) and C)
F) C) and D)

Question 17

C4 binding protein (C4BP) acts in association with which factor to inactivate C4b?

Accepted Answer

A)   Factor B
B)   Factor D
C)   Factor I
D)   C1INHE) C) and D)
F) A) and B)

Question 18

Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

Accepted Answer

A)   C2
B)   C3
C)   C4
D)   Factor BE) A) and C)
F) A) and B)

Question 19

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

Accepted Answer

A)   C3bBb3b
B)   C4b2a
C)   C5b6789
D)   C3bE) B) and D)
F) All of the above

Question 20

Identify the condition that would result from a deficiency in complement component C2.

Accepted Answer

A)   Increased vascular permeability
B)   Hereditary angioedema
C)   Severe infections with encapsulated bacteria
D)   Immune complex diseaseE) A) and D)
F) B) and C)

Exam 7: Complement System

Identify the condition that would result from a deficiency in complement component C2.

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The lectin pathway is initiated by the presence of which of the following?

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Which of the following immunoglobulins is able to activate complement?

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In the alternate pathway,factor B must bind to which of the following to initiate the cascade?

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Lack of the complement inhibitor C1INH results in which disease?

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C4 binding protein (C4BP) acts in association with which factor to inactivate C4b?

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Which of the following is cleaved first by C1qrs in the classical pathway of complement activation?

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Which of the following acts as an opsonin?

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Formation of the membrane attack complex (C5b-C9) is stopped by which factor?

Correct AnswerverifiedShow Answer

What reagent is present in a CH50 assay and absent in an AH50 assay?

Correct AnswerverifiedShow Answer

Binding of a lectin to a sugar found in bacteria and fungi occurs in which complement pathway?

Correct AnswerverifiedShow Answer

Which statement about complement components is most accurate?

Correct AnswerverifiedShow Answer

Kidney glomeruli can become obstructed with immune complexes as a result of:

Correct AnswerverifiedShow Answer

Chemotactic and anaphylactic factors are produced by proteolytic cleavage of:

Correct AnswerverifiedShow Answer

Which of the following is a characteristic of complement?

Correct AnswerverifiedShow Answer

Which of the following represents C3 convertase?

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Which of the following is the correct order of activation of complement in the lectin activation pathway?

Correct AnswerverifiedShow Answer

Lack of the complement components C5 through C9 may result in which condition?

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Which factors are found in all three pathways?

Correct AnswerverifiedShow Answer

Which of the following functions by inserting itself into target membranes and forming channels or holes in the membranes?

Correct AnswerverifiedShow Answer

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